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small molecule hh inhibitor  (PellePharm)

 
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    PellePharm small molecule hh inhibitor
    Small Molecule Hh Inhibitor, supplied by PellePharm, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/small+molecule+hh+inhibitor/10__1016_slash_j__jid__2019__03__755-55-5-1?v=PellePharm
    Average 90 stars, based on 1 article reviews
    small molecule hh inhibitor - by Bioz Stars, 2026-08
    90/100 stars

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    HH pathway inhibition reduces EHBD cell proliferation after acute injury. EHBDs of WT and Gli1 −/− mice were examined 24‐h after operation with H&E (A) and immunofluorescence (B) (proliferating cells, EdU, green; epithelial cells, CK19, red). Proliferating cells were enumerated and compared with WT controls (C). Experimental schema of WT mice treated with the Vehicle (Veh) or HH inhibitor <t>LDE225</t> (LDE) before sham or BDL operation with analysis after 24 h (D). LDE‐ or Veh‐treated mouse EHBDs were examined with H&E (E) and immunofluorescence (F). Morphometric analysis of LDE‐ or Veh‐treated mice (G) where proliferating cells were enumerated and compared with Veh‐treated controls. Proliferating cells were expressed as a percentage of all epithelial cells in the CK19 + cell compartment. Asterisks mark EHBD lumen; arrows and arrowheads mark epithelial and stromal cells, respectively. The data are presented as the mean ± SEM. *** p < 0.001, **** p < 0.0001. n = 3–5 mice/group. One‐way ANOVA. Scale bars, 50 μm
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    HH pathway inhibition reduces EHBD cell proliferation after acute injury. EHBDs of WT and Gli1 −/− mice were examined 24‐h after operation with H&E (A) and immunofluorescence (B) (proliferating cells, EdU, green; epithelial cells, CK19, red). Proliferating cells were enumerated and compared with WT controls (C). Experimental schema of WT mice treated with the Vehicle (Veh) or HH inhibitor <t>LDE225</t> (LDE) before sham or BDL operation with analysis after 24 h (D). LDE‐ or Veh‐treated mouse EHBDs were examined with H&E (E) and immunofluorescence (F). Morphometric analysis of LDE‐ or Veh‐treated mice (G) where proliferating cells were enumerated and compared with Veh‐treated controls. Proliferating cells were expressed as a percentage of all epithelial cells in the CK19 + cell compartment. Asterisks mark EHBD lumen; arrows and arrowheads mark epithelial and stromal cells, respectively. The data are presented as the mean ± SEM. *** p < 0.001, **** p < 0.0001. n = 3–5 mice/group. One‐way ANOVA. Scale bars, 50 μm
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    HH pathway inhibition reduces EHBD cell proliferation after acute injury. EHBDs of WT and Gli1 −/− mice were examined 24‐h after operation with H&E (A) and immunofluorescence (B) (proliferating cells, EdU, green; epithelial cells, CK19, red). Proliferating cells were enumerated and compared with WT controls (C). Experimental schema of WT mice treated with the Vehicle (Veh) or HH inhibitor <t>LDE225</t> (LDE) before sham or BDL operation with analysis after 24 h (D). LDE‐ or Veh‐treated mouse EHBDs were examined with H&E (E) and immunofluorescence (F). Morphometric analysis of LDE‐ or Veh‐treated mice (G) where proliferating cells were enumerated and compared with Veh‐treated controls. Proliferating cells were expressed as a percentage of all epithelial cells in the CK19 + cell compartment. Asterisks mark EHBD lumen; arrows and arrowheads mark epithelial and stromal cells, respectively. The data are presented as the mean ± SEM. *** p < 0.001, **** p < 0.0001. n = 3–5 mice/group. One‐way ANOVA. Scale bars, 50 μm
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    HH pathway inhibition reduces EHBD cell proliferation after acute injury. EHBDs of WT and Gli1 −/− mice were examined 24‐h after operation with H&E (A) and immunofluorescence (B) (proliferating cells, EdU, green; epithelial cells, CK19, red). Proliferating cells were enumerated and compared with WT controls (C). Experimental schema of WT mice treated with the Vehicle (Veh) or HH inhibitor LDE225 (LDE) before sham or BDL operation with analysis after 24 h (D). LDE‐ or Veh‐treated mouse EHBDs were examined with H&E (E) and immunofluorescence (F). Morphometric analysis of LDE‐ or Veh‐treated mice (G) where proliferating cells were enumerated and compared with Veh‐treated controls. Proliferating cells were expressed as a percentage of all epithelial cells in the CK19 + cell compartment. Asterisks mark EHBD lumen; arrows and arrowheads mark epithelial and stromal cells, respectively. The data are presented as the mean ± SEM. *** p < 0.001, **** p < 0.0001. n = 3–5 mice/group. One‐way ANOVA. Scale bars, 50 μm

    Journal: Hepatology (Baltimore, Md.)

    Article Title: C‐X‐C motif chemokine ligand 1 induced by Hedgehog signaling promotes mouse extrahepatic bile duct repair after acute injury

    doi: 10.1002/hep.32492

    Figure Lengend Snippet: HH pathway inhibition reduces EHBD cell proliferation after acute injury. EHBDs of WT and Gli1 −/− mice were examined 24‐h after operation with H&E (A) and immunofluorescence (B) (proliferating cells, EdU, green; epithelial cells, CK19, red). Proliferating cells were enumerated and compared with WT controls (C). Experimental schema of WT mice treated with the Vehicle (Veh) or HH inhibitor LDE225 (LDE) before sham or BDL operation with analysis after 24 h (D). LDE‐ or Veh‐treated mouse EHBDs were examined with H&E (E) and immunofluorescence (F). Morphometric analysis of LDE‐ or Veh‐treated mice (G) where proliferating cells were enumerated and compared with Veh‐treated controls. Proliferating cells were expressed as a percentage of all epithelial cells in the CK19 + cell compartment. Asterisks mark EHBD lumen; arrows and arrowheads mark epithelial and stromal cells, respectively. The data are presented as the mean ± SEM. *** p < 0.001, **** p < 0.0001. n = 3–5 mice/group. One‐way ANOVA. Scale bars, 50 μm

    Article Snippet: [ ] LDE225, a small molecule inhibitor of the HH signaling protein Smoothened, was used for pharmacologic inhibition of HH signaling (Chemietek).

    Techniques: Inhibition, Immunofluorescence